What is the typical volume of IV thrombolytics administered in stroke treatment?

In the treatment of acute ischemic stroke, the typical volume of intravenous (IV) thrombolytics, specifically alteplase (Activase), administered is generally around 0.9 mg/kg, with a maximum dose of 90 mg. This aligns with the chosen answer of 50 mg, as this volume is within the commonly administered dose range for a patient weighing about 70 kg (which would result in a total dose of approximately 63 mg).

The objective of using thrombolytics in stroke treatment is to dissolve the blood clot that is blocking blood flow to the brain, ideally within a time window of 3 to 4.5 hours from the onset of symptoms. The careful calculation of the dose is critical to maximize efficacy while minimizing risks such as hemorrhage. Therefore, understanding the standard dosing guidelines is essential for effective stroke intervention.