When is it appropriate to use high-dose epinephrine in ACLS?

High-dose epinephrine is generally not recommended in the current Advanced Cardiovascular Life Support (ACLS) guidelines due to the lack of evidence supporting its superiority over standard-dose epinephrine. Research has shown that using the standard dose of epinephrine is effective in critical situations such as cardiac arrest, while high doses do not provide additional benefit and may even pose risks, such as increased myocardial oxygen demand and adverse outcomes.

In fact, the focus of ACLS has shifted toward optimizing the use of standard doses of medications alongside effective CPR and defibrillation. This approach emphasizes the importance of a streamlined and evidence-based practice in resuscitation efforts to improve patient outcomes. The guidelines, therefore, recommend sticking to the standard dose, reinforcing the importance of adhering to current evidence in resuscitation protocols.